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This route of administration is used when giving medicine is not possible by mouth, patient is unconscious or is in convulsions. Medicine used is absorbed by rectal mucosa and reaches blood. Suppository is inserted about an inch inside anus, that is the last end of several feet long gastro-intestinal tract. Peristaltic movement in gut makes it one-way street and therefore anything pushed in to anus can not reach stomach that is long distance away. Suppository dissolves and releases drug in rectum only. Sometimes it is pushed out even before dissolving.
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